IVF+PGD Treatment
Pre-Implantation Genetic Testing can be done to all IVF treatments. When PGD is done we do the 5 major genetic screaning of the embryo.
PGD can detect single gene defect disorders that can result in such diseases as:
- muscular dystrophy,
- sickle cell anemia, cystic fibrosisand Tay-Sachs.
PGS can detect genetic conditions such as;
- Trisomy 21,
- Down syndrome,
- Trisomy 18, known as Edwards syndrome.
Once these are done with the PGD proccess we can then transfer a healthy embryo. The proccess is the same as IVF/ICSI with adminestering hormone injections to help the follicles grow. The PGD proccess is done after the eggs are retrieved and is fertilized with ICSI. The PGD proccess is on day 3 and day 5 of the embryos progress. Day 5 or 6 the healthy embryos are transferred to the female patients utures.
Preimplantation Genetic Screening
Preimplantation genetic diagnosis (PGD) also known as Preimplantation Genetic Screening (PGS) is a procedure used prior to implantation to help identify genetic defects within embryos. PGD proccedure while the embryo is developing, prevent certain genetic diseases or disorders from being passed on to the child. The embryos are tested for a panel of chromosome genetic abnormalities so that only the unaffected embryos a implanted back to the femals utures to result healthy pregnancy.
PGD was developed as an alternative to prenatal diagnosis and potentional termination of a fetus affected by genenetic disease.
How is PGD performed
Preimplantation genetic diagnosis begins with the same process of in vitro fertilization IVF that includes egg retrieval and fertilization in a laboratory. After the egg retrieval has been preformed, the embryos have three to five days to develop, the embryos will divide into multiple cells. First, a few cells are micro-surgically removed from the embryos, which are either day 3 or 5 developed, depending on the chromosomes that are being tested in the biopsy. In most cases, the chromosomal biopsy will take place on day 3 and is referred to as cleavage stage biopsy, the results will be available on day 4 and we can proceed with the transfer on day 5. The results will be available in time for the embryo transfer day. Once PGD has identified embryos free of genetic problems, the healthiest embryos are then selected and can then be transferred to the uterus
Who can benefit from PGD
Preimplantation genetic diagnosis can benefit any couple at risk for passing on a genetic disease or condition.
The following is a list of the type of individuals who are possible candidates for PGD:
- A history of miscarriages due to genetic disorders
- Repeated IVF failures
- Male partners with severe male factor infertility
- An existing child with a genetic disease
- Requiring a tissue match for an ill sibling
- A family history of X-linked disorders
- Chromosome translocations, which can cause implantation failure, recurrent pregnancy loss, mental and physical disorders in children
- Autosomal recessive diseases, such as cystic fibrosis, sickle cell anaemia and Tay Sachs disease
- Autosomal dominat diseases, including dwarfism and Huntingtn’s disease
Pre-Implantation Genetic Testing can be done to all IVF treatments. When PGD is done we do the 5 major genetic screaning of the embryo.
PGD can detect single gene defect disorders that can result in such diseases as:
- muscular dystrophy,
- sickle cell anemia, cystic fibrosisand Tay-Sachs.
PGS can detect genetic conditions such as;
- Trisomy 21,
- Down syndrome,
- Trisomy 18, known as Edwards syndrome.
Once these are done with the PGD proccess we can then transfer a healthy embryo. The proccess is the same as IVF/ICSI with adminestering hormone injections to help the follicles grow. The PGD proccess is done after the eggs are retrieved and is fertilized with ICSI. The PGD proccess is on day 3 and day 5 of the embryos progress. Day 5 or 6 the healthy embryos are transferred to the female patients utures.